Amikacin assays for patients on conventional divided doses (tds or bd) or other regimens: Target range and Results interpretation.

Pre-dose level

• The pre-dose level must be low to minimise toxicity.
• The target range is <10 mg/L.
• Remember that apparently high levels may be due to mis-timing of the samples.

Post-dose level

• The post-dose level must be adequate to ensure efficacy.
• For most infections the target is >20mg/L.

• If the assay result is normal, and there is no change in dose or renal function, twice weekly monitoring of the pre-dose level is recommended. 
• If the assay result is abnormal, contact microbiology for advice on further management.

Page last edited: 29/10/2008

Caution; the antibiotic doses recommended on this website are intended for adult patients with normal renal and liver function unless otherwise stated. Dosing advice for patients with renal impairment is available here.

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